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Article

Germline APC Alterations May Predispose to Testicular Sex Cord-Stromal Tumors.

The American journal of surgical pathology - 1 Dec 2023

Siegmund Stephanie, Ricci Costantino, Kao Chia-Sui, Sangoi Ankur R, Mohanty Sambit, Fletcher Christopher D M, Colecchia Maurizio, Acosta Andres M

Abstract excerpt

Sertoli cell tumor is a type of testicular sex cord-stromal tumor (TSCST) typically driven by gain-of-function CTNNB1 variants. Recently, molecular studies have identified TSCSTs (including Sertoli cell tumors) with loss-of-function APC variants, raising the possibility that germline APC alterations may predispose to TSCSTs. In this study, we evaluated 4 TSCSTs from 4 individual patients, including 3 APC -mutant...

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Identifiers

PMID: 37811860
DOI: 10.1097/PAS.0000000000002132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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