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Article

Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse.

Biology of reproduction - 1 Nov 2009

Chang Hao, Guillou Florian, Taketo Makoto M, Behringer Richard R

Abstract excerpt

Overactive WNT/beta-catenin signaling has been found in many forms of cancer in human patients. Mouse models with mutations in different components of the WNT/beta-catenin signaling pathway have been generated to mimic tumorigenesis in humans. Mice with mutations that result in overactive WNT/beta-catenin signaling developed tumors in some tissues, such as digestive tract, skin, and ovary, but they failed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19553598
DOI: 10.1095/biolreprod.109.077446
PMCID: PMC2770017

Genes

AMH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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