Article
The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis.
Virchows Archiv : an international journal of pathology - 1 Apr 2017
Bremmer F, Behnes C L, Schildhaus H U, Gaisa N T, Reis H, Jarry H, Radzun H J, Stroebel P, Schweyer S
Abstract excerpt
The WHO classification of testis tumours includes the group of sex cord-stromal tumours. They are divided into several histological types, i.e. Leydig cell (LCT) and Sertoli cell tumours (SCT). Based on the physiological expression of β-catenin in normal testis/Sertoli cells, it was previously shown that SCT can carry a β-catenin mutation, causing a nuclear positivity for β-catenin and cyclin D1. Furthermore, it...
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