Article
β-Catenin alterations in testicular Leydig cell tumour: a immunohistochemical and molecular analysis.
Histopathology - 1 Jul 2024
Kitagawa Yukiko, De Biase Dario, Ricci Costantino, Cornejo Kristine M, Fiorentino Michelangelo, Collins Katrina, Idrees Muhammad T, Colecchia Maurizio, Ulbright Thomas M, Acosta Andres Martin
Abstract excerpt
BACKGROUND: Testicular Leydig cell tumours (LCTs) are the most common type of sex cord-stromal tumour in men, representing 1%-3% of all testicular neoplasms. Among testicular sex cord-stromal tumours, CTNNB1 mutations and nuclear expression of β-catenin have been typically associated with Sertoli cell tumour. Recent genomic analyses have shown that CTNNB1 variants are also identified in a subset of LCTs; however,...
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