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Article

Improving the efficacy of anti-EGFR drugs in GBM: Where we are going?

Biochimica et biophysica acta. Reviews on cancer - 1 Nov 2023

Ge Manxi, Zhu Yan, Wei Minjie, Piao Haozhe, He Miao

Abstract excerpt

The therapies targeting mutations of driver genes in cancer have advanced into clinical trials for a variety of tumors. In glioblastoma (GBM), epidermal growth factor receptor (EGFR) is the most commonly mutated oncogene, and targeting EGFR has been widely investigated as a promising direction. However, the results of EGFR pathway inhibitors have not been satisfactory. Limited blood-brain barrier (BBB)...

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PMID: 37805108
DOI: 10.1016/j.bbcan.2023.188996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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