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Article

Targeting EGFR for Treatment of Glioblastoma: Molecular Basis to Overcome Resistance

1 Mar 2012

Abstract excerpt

Glioblastoma (glioblastoma multiforme; GBM; WHO Grade IV) accounts for the majority of primary malignant brain tumors in adults. Amplification and mutation of the epidermal growth factor receptor (EGFR) gene represent signature genetic abnormalities encountered in GBM. A range of potential therapies that target EGFR or its mutant constitutively active form, ΔEGFR, including tyrosine kinase inhibitors (TKIs),...

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PMID: 22268382
DOI: 10.2174/156800912799277557

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