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Article

Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations.

Chinese journal of cancer - 1 Jan 2011

Wykosky Jill, Fenton Tim, Furnari Frank, Cavenee Webster K

Abstract excerpt

Epidermal growth factor receptor (EGFR) is one of the most commonly altered genes in human cancer by way of over-expression, amplification, and mutation. Targeted inhibition of EGFR activity suppresses signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. Small molecule tyrosine kinase inhibitors and monoclonal antibodies are among the most common EGFR-targeting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21192840
DOI: 10.5732/cjc.010.10542
PMCID: PMC3359794

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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