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Article

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.

FEBS letters - 3 Sept 2008

Bleicher Lucas, de Moura Patricia Ribeiro, Watanabe Leandra, Colau Didier, Dumoutier Laure, Renauld Jean-Christophe, Polikarpov Igor

Abstract excerpt

Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9A crystal structure of the...

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PMID: 18675809
DOI: 10.1016/j.febslet.2008.07.046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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