Article
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study.
American journal of human genetics - 5 Oct 2023
Wang Yuxuan, Selvaraj Margaret Sunitha, Li Xihao, Li Zilin, Holdcraft Jacob A, Arnett Donna K, Bis Joshua C, Blangero John, Boerwinkle Eric, Bowden Donald W, Cade Brian E, Carlson Jenna C, Carson April P, Chen Yii-Der Ida, Curran Joanne E, de Vries Paul S, Dutcher Susan K, Ellinor Patrick T, Floyd James S, Fornage Myriam, Freedman Barry I, Gabriel Stacey, Germer Soren, Gibbs Richard A, Guo Xiuqing, He Jiang, Heard-Costa Nancy, Hildalgo Bertha, Hou Lifang, Irvin Marguerite R, Joehanes Roby, Kaplan Robert C, Kardia Sharon Lr, Kelly Tanika N, Kim Ryan, Kooperberg Charles, Kral Brian G, Levy Daniel, Li Changwei, Liu Chunyu, Lloyd-Jone Don, Loos Ruth Jf, Mahaney Michael C, Martin Lisa W, Mathias Rasika A, Minster Ryan L, Mitchell Braxton D, Montasser May E, Morrison Alanna C, Murabito Joanne M, Naseri Take, O'Connell Jeffrey R, Palmer Nicholette D, Preuss Michael H, Psaty Bruce M, Raffield Laura M, Rao Dabeeru C, Redline Susan, Reiner Alexander P, Rich Stephen S, Ruepena Muagututi'a Sefuiva, Sheu Wayne H-H, Smith Jennifer A, Smith Albert, Tiwari Hemant K, Tsai Michael Y, Viaud-Martinez Karine A, Wang Zhe, Yanek Lisa R, Zhao Wei, Rotter Jerome I, Lin Xihong, Natarajan Pradeep, Peloso Gina M
Abstract excerpt
Long non-coding RNAs (lncRNAs) are known to perform important regulatory functions in lipid metabolism. Large-scale whole-genome sequencing (WGS) studies and new statistical methods for variant set tests now provide an opportunity to assess more associations between rare variants in lncRNA genes and complex traits across the genome. In this study, we used high-coverage WGS from 66,329 participants of diverse...
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