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DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis †

20 Feb 2017

Abstract excerpt

Spermatogonial stem cells (SSC) are essential for spermatogenesis and male fertility. In addition, these adult tissue stem cells can be used as vehicles for germline modification in animal models and may have application for treating male infertility. To facilitate the investigation of SSCs and germ lineage development in rats, we generated a DEAD-box helicase 4 (DDX4) (VASA) promoter-enhanced green fluorescent...

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PMID: 28339678
DOI: 10.1095/biolreprod.116.142828

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