Article
A practical assembly guideline for genomes with various levels of heterozygosity.
Briefings in bioinformatics - 22 Sept 2023
Mochizuki Takako, Sakamoto Mika, Tanizawa Yasuhiro, Nakayama Takuro, Tanifuji Goro, Kamikawa Ryoma, Nakamura Yasukazu
Abstract excerpt
Although current long-read sequencing technologies have a long-read length that facilitates assembly for genome reconstruction, they have high sequence errors. While various assemblers with different perspectives have been developed, no systematic evaluation of assemblers with long reads for diploid genomes with varying heterozygosity has been performed. Here, we evaluated a series of processes, including the...
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