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Article

A Genetic Algorithm for Diploid Genome Reconstruction Using Paired-End Sequencing.

PloS one - 1 Jan 2016

Ting Chuan-Kang, Lin Choun-Sea, Chan Ming-Tsai, Chen Jian-Wei, Chuang Sheng-Yu, Huang Yao-Ting

Abstract excerpt

The genome of many species in the biosphere is a diploid consisting of paternal and maternal haplotypes. The differences between these two haplotypes range from single nucleotide polymorphisms (SNPs) to large-scale structural variations (SVs). Existing genome assemblers for next-generation sequencing platforms attempt to reconstruct one consensus sequence, which is a mosaic of two parental haplotypes....

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PMID: 27861560
DOI: 10.1371/journal.pone.0166721
PMCID: PMC5115803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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