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Reference-guided genome assembly at scale using ultra-low-coverage high-fidelity long-reads with HiFiCCL

2025-04-24

Abstract excerpt

Population genomics using short-read resequencing captures single nucleotide polymorphisms and small insertions and deletions but struggles with structural variants (SVs), leading to a loss of heritability in genome-wide association studies. In recent years, long-read sequencing has improved pangenome construction for key eukaryotic species, addressing this issue to some extent. Sufficient-coverage high-fidelity (...

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Literature Corpus work: 9314cde7-93c6-513f-914f-38b5e98d494c
DOI: 10.1101/2025.04.20.649739

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