Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype considerations for virus-like particle-based bivalent norovirus vaccine composition.

Clinical and vaccine immunology : CVI - 1 Jun 2015

Malm Maria, Tamminen Kirsi, Lappalainen Suvi, Uusi-Kerttula Hanni, Vesikari Timo, Blazevic Vesna

Abstract excerpt

Norovirus (NoV) genogroup I (GI) and GII are responsible for most human infections with NoV. Because of the high genetic variability of NoV, natural infection does not induce sufficient protective immunity to different genotypes or to variants of the same genotype and there is little or no cross-protection against different genogroups. NoV-derived virus-like particles (VLPs) are promising vaccine candidates that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caliciviridae Infections

Share to Cross Protection

Share to Cross Reactions

Share to Immunoglobulin G

Share to Norovirus

Share to Viral Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 25903355
DOI: 10.1128/CVI.00015-15
PMCID: PMC4446402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype considerations for virus-like particle-based bivalent norovirus vaccine composition.PMID 25903355Read ↗

Functionality and avidity of norovirus-specific antibodies and T cells induced by GII.4 virus-like particles alone or co-administered with different genotypes.Semantic proximity Read ↗

Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus Than Sequential Immunization.Semantic proximity Read ↗

Epidemiology of human noroviruses and updates on vaccine development.Semantic proximity Read ↗

Chimeric GII.4 Norovirus Virus-Like-Particle-Based Vaccines Induce Broadly Blocking Immune ResponsesSemantic proximity Read ↗

Vaccine against norovirus.Semantic proximity Read ↗

Safety and Immunogenicity of Different Formulations of Norovirus Vaccine Candidate in Healthy Adults: A Randomized, Controlled, Double-Blind Clinical Trial.Semantic proximity Read ↗

Chimeric virus-like particles of human norovirus constructed by structure-guided epitope grafting elicit cross-reactive immunity against both GI.1 and GII.4 genotypes.Semantic proximity Read ↗

Immunogenicity and specificity of norovirus Consensus GII.4 virus-like particles in monovalent and bivalent vaccine formulations.Semantic proximity Read ↗

Characterization of virus-like particles derived from a GII.3 norovirus strain distantly related with current dominating strains.Semantic proximity Read ↗

Genetic and antigenic diversity among noroviruses.Semantic proximity Read ↗

A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccineSemantic proximity Read ↗

A quadrivalent norovirus vaccine based on a chimpanzee adenovirus vector induces potent immunity in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.