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Article

DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis.

Nucleic acids research - 10 Nov 2023

Lózsa Rita, Németh Eszter, Gervai Judit Z, Márkus Bence G, Kollarics Sándor, Gyüre Zsolt, Tóth Judit, Simon Ferenc, Szüts Dávid

Abstract excerpt

DNA mismatch repair (MMR) corrects mismatched DNA bases arising from multiple sources including polymerase errors and base damage. By detecting spontaneous mutagenesis using whole genome sequencing of cultured MMR deficient human cell lines, we show that a primary role of MMR is the repair of oxygen-induced mismatches. We found an approximately twofold higher mutation rate in MSH6 deficient DLD-1 cells or MHL1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37791890
DOI: 10.1093/nar/gkad775
PMCID: PMC10639081

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