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Article

APOE-Genotype and Insulin Modulate Estimated Effect of Dietary Macronutrients on Cognitive Performance: Panel Analyses in Nondiabetic Older Adults at Risk of Dementia.

The Journal of nutrition - 1 Dec 2023

Norgren Jakob, Sindi Shireen, Matton Anna, Kivipelto Miia, Kåreholt Ingemar

Abstract excerpt

BACKGROUND: The apolipoprotein E gene (APOE ε-2/3/4, combined as 6 different genotypes: ε-22/23/24/33/34/44) and insulin status modulate dementia risk and play a role in the metabolism of macronutrients. OBJECTIVES: We aimed to examine APOE-genotype and fasting insulin as effect modifiers of the slopes between dietary macronutrients and cognitive performance among older adults at risk of dementia. METHODS: Panel...

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PMID: 37778510
DOI: 10.1016/j.tjnut.2023.09.016

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