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Article

Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial.

Brain : a journal of neurology - 7 Feb 2026

Saadmaan Gazi, Dalmasso Maria Carolina, Maria Maleeha, Lehtisalo Jenni, Hiltunen Mikko, Kaikkonen Minna U, Levälahti Esko, Mangialasche Francesca, Perola Markus, Ramirez Alfredo, Stephen Ruth, Ngandu Tiia, Kivipelto Miia, Solomon Alina

Abstract excerpt

Alzheimer's disease and coronary artery disease are common late-life chronic conditions and share multiple risk factors, including the apolipoprotein E (APOE) ε4 allele. A meta-analysis of two multidomain lifestyle intervention trials found greater cognitive benefits in APOE4 carriers compared with non-carriers. This study investigated the impact of genetic risk scores for Alzheimer's disease and coronary artery...

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Source

Identifiers

PMID: 40747850
DOI: 10.1093/brain/awaf277

Genes

CAD
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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