Article
Context-dependent roles of cellular senescence in normal, aged, and disease states.
The FEBS journal - 1 Mar 2023
Moiseeva Victoria, Cisneros Andrés, Cobos Aina Calls, Tarrega Aida Beà, Oñate Claudia Santos, Perdiguero Eusebio, Serrano Antonio L, Muñoz-Cánoves Pura
Abstract excerpt
Cellular senescence is a state of irreversible cell cycle arrest that often emerges after tissue damage and in age-related diseases. Through the production of a multicomponent secretory phenotype (SASP), senescent cells can impact the regeneration and function of tissues. However, the effects of senescent cells and their SASP are very heterogeneous and depend on the tissue environment and type as well as the...
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