Article
Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties.
Cells - 19 Sept 2023
Chertkova Rita V, Oleynikov Ilya P, Pakhomov Alexey A, Sudakov Roman V, Orlov Victor N, Semenova Marina A, Arutyunyan Alexander M, Ptushenko Vasily V, Kirpichnikov Mikhail P, Dolgikh Dmitry A, Vygodina Tatiana V
Abstract excerpt
Cytochrome c (CytC) is a single-electron carrier between complex bc1 and cytochrome c-oxidase (CcO) in the electron transport chain (ETC). It is also known as a good radical scavenger but its participation in electron flow through the ETC makes it impossible to use CytC as a radical sensor. To solve this problem, a series of mutants were constructed with substitutions of Lys residues in the universal binding site...
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