[Molecular effects of mitochondrial mutations in cytochrome b of complex III and their impact on the levels of free radical production].

Abstract excerpt

Cytochrome bc1 (mitochondrial complex III) is a common element of several bioenergetic systems. This enzyme catalyses electron transfer from ubiquinol to cytochrome c coupled to translocation of protons across the membrane, which contributes to generation of protonmotive force utilized for ATP production. Cytochrome b, together with cytochrome c1 and iron-sulfur protein (ISP), forms the evolutionarily conserved...

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