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Article

ROS production by cytochrome bc1: Its mechanism as inferred from the effects of heme b cofactor mutants.

Biochimica et biophysica acta. Bioenergetics - 1 Jan 2025

Pagacz Jakub, Borek Arkadiusz, Osyczka Artur

Abstract excerpt

Cytochrome bc1 is one of the enzymes of electron transport chain responsible for generation of reactive oxygen species (ROS). While ROS are considered to be products of side reactions of quinol oxidation site (Qo), molecular aspects of their generation remain unclear. One of them concerns significance of hemes b (bL and bH) redox potentials (Em) and properties on ROS generation by Qo. Here we addressed this...

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PMID: 39326544
DOI: 10.1016/j.bbabio.2024.149513

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