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ROS signaling capacity of cytochrome bc1: Opposing effects of adaptive and pathogenic mitochondrial mutations.

Free radical biology & medicine - 1 Feb 2021

Pagacz Jakub, Broniec Agnieszka, Wolska Małgorzata, Osyczka Artur, Borek Arkadiusz

Abstract excerpt

Cytochrome bc1, also known as mitochondrial complex III, is considered to be one of the important producers of reactive oxygen species (ROS) in living organisms. Under physiological conditions, a certain level of ROS produced by mitochondrial electron transport chain (ETC) might be beneficial and take part in cellular signaling. However, elevated levels of ROS might exhibit negative effects, resulting in cellular...

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PMID: 33352219
DOI: 10.1016/j.freeradbiomed.2020.12.019

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