Article
The Increase in the Peroxidase Activity of the Cytochrome C with Substitutions in the Universal Binding Site Is Associated with Changes in the Ability to Interact with External Ligands.
International journal of molecular sciences - 28 Jul 2024
Chertkova Rita V, Oleynikov Ilya P, Pakhomov Alexey A, Sudakov Roman V, Semenova Marina A, Arutyunyan Alexander M, Ptushenko Vasily V, Kirpichnikov Mikhail P, Dolgikh Dmitry A, Vygodina Tatiana V
Abstract excerpt
Cytochrome c (CytC), a one-electron carrier, transfers electrons from complex bc1 to cytochrome c oxidase (CcO) in the electron-transport chain. Electrostatic interaction with the partners, complex bc1 and CcO, is ensured by a lysine cluster near the heme forming the Universal Binding Site (UBS). We constructed three mutant variants of mitochondrial CytC with one (2Mut), four (5Mut), and five (8Mut) Lys->Glu...
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