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Article

Phosphomimetic substitution of cytochrome C tyrosine 48 decreases respiration and binding to cardiolipin and abolishes ability to trigger downstream caspase activation.

Biochemistry - 10 Aug 2010

Pecina Petr, Borisenko Grigory G, Belikova Natalia A, Tyurina Yulia Y, Pecinova Alena, Lee Icksoo, Samhan-Arias Alejandro K, Przyklenk Karin, Kagan Valerian E, Hüttemann Maik

Abstract excerpt

Mammalian cytochrome c (Cytc) transfers electrons from the bc(1) complex to cytochrome c oxidase (CcO) as part of the mitochondrial electron transport chain, and it also participates in type II apoptosis. Our recent discovery of two tyrosine phosphorylation sites in Cytc, Tyr97 in bovine heart and Tyr48 in bovine liver, indicates that Cytc functions are regulated through cell signaling. To characterize the role...

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PMID: 20586425
DOI: 10.1021/bi100486s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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