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Article

OGG1 is a novel prognostic indicator in acute myeloid leukaemia.

Oncogene - 1 Apr 2010

Liddiard K, Hills R, Burnett A K, Darley R L, Tonks A

Abstract excerpt

OGG1 (8-oxoguanine DNA glycosylase) constitutes a key component of the DNA base excision repair pathway, catalysing the removal of 8-oxoguanine nucleotides from DNA, thereby suppressing mutagenesis and cell death. We found that OGG1 expression was significantly downregulated by the RUNX1-ETO fusion protein product of the t(8;21) chromosome translocation in normal haematopoietic progenitor cells and in patients...

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Source

Identifiers

PMID: 20023702
DOI: 10.1038/onc.2009.462

Genes

OGG1
FLT3
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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