Article

Inhibition of pyrimidine biosynthesis targets protein translation in AML

2021-09-24

Abstract excerpt

The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes one of the rate-limiting steps in de novo pyrimidine biosynthesis, a pathway that provides essential metabolic precursors for nucleic acids, glycoproteins and phospholipids. DHODH inhibitors (DHODHi) are clinically used for autoimmune diseases and are emerging as a novel class of anti-cancer agents, especially in acute myeloid leukemia (AML)...

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Literature Corpus work: 29670876-89e5-5b0c-bc57-18073ebf3baf
DOI: 10.1101/2021.09.24.461627

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