Article

Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia

2026-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Internal tandem duplication mutations in FLT3 ( FLT3 ITD ) occur in approximately 30% of patients with acute myeloid leukemia (AML) and are among the most common genetic alterations in this disease. FLT3 ITD is a major driver of AML and is associated with poor clinical outcomes. Although FLT3 inhibitors (FLT3is) have significantly improved outcomes for patients with FLT3 ITD + AML, acquired...

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Literature Corpus work: bd78d140-5c3f-57fc-be6c-2f2ca5f02435
DOI: 10.64898/2026.07.21.736123

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