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ANO7 African-ancestral genomic diversity and advanced prostate cancer.

Prostate cancer and prostatic diseases - 1 Sept 2024

Jiang Jue, Soh Pamela X Y, Mutambirwa Shingai B A, Bornman M S Riana, Haiman Christopher A, Hayes Vanessa M, Jaratlerdsiri Weerachai

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) is a significant health burden for African men, with mortality rates more than double global averages. The prostate specific Anoctamin 7 (ANO7) gene linked with poor patient outcomes has recently been identified as the target for an African-specific protein-truncating PCa-risk allele. METHODS: Here we determined the role of ANO7 in a study of 889 men from southern Africa,...

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Identifiers

PMID: 37749167
DOI: 10.1038/s41391-023-00722-x
PMCID: PMC11319200

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