Article
Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers.
Genome medicine - 31 Aug 2022
Gong Tingting, Jaratlerdsiri Weerachai, Jiang Jue, Willet Cali, Chew Tracy, Patrick Sean M, Lyons Ruth J, Haynes Anne-Maree, Pasqualim Gabriela, Brum Ilma Simoni, Stricker Phillip D, Mutambirwa Shingai B A, Sadsad Rosemarie, Papenfuss Anthony T, Bornman Riana M S, Chan Eva K F, Hayes Vanessa M
Abstract excerpt
BACKGROUND: African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the region has largely been excluded from the benefits of whole genome interrogation studies. Additionally, while structural variation (SV) is highly prevalent, PCa genomic studies are still biased towards small variant...
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