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Article

The genetic architecture of biological age in nine human organ systems.

Nature aging - 1 Sept 2024

Wen Junhao, Tian Ye Ella, Skampardoni Ioanna, Yang Zhijian, Cui Yuhan, Anagnostakis Filippos, Mamourian Elizabeth, Zhao Bingxin, Toga Arthur W, Zalesky Andrew, Davatzikos Christos

Abstract excerpt

Investigating the genetic underpinnings of human aging is essential for unraveling the etiology of and developing actionable therapies for chronic diseases. Here, we characterize the genetic architecture of the biological age gap (BAG; the difference between machine learning-predicted age and chronological age) across nine human organ systems in 377,028 participants of European ancestry from the UK Biobank. The...

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Identifiers

PMID: 38942983
DOI: 10.1038/s43587-024-00662-8
PMCID: PMC11446180

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