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Article

Pleiotropy and disease interactors: the dual nature of genes linking ageing and ageing-related diseases.

Biogerontology - 29 Apr 2026

Vega Magdaleno Gustavo Daniel, de Magalhães João Pedro

Abstract excerpt

Ageing-related diseases (ARDs) display diverse phenotypes yet share an age-dependent rise in incidence, suggesting mechanistic links with ageing processes. We examined whether ageing-related genes differ systematically from genes associated with multiple ARD clusters. Across 57 ARDs from UK Biobank, network analyses showed that ageing-related genes, although rarely ARD-associated, lie significantly closer to many...

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Identifiers

PMID: 42050229
DOI: 10.1007/s10522-026-10429-w
PMCID: PMC13124933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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