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Article

A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes.

Nature - 1 Nov 2023

Sanderson Theo, Hisner Ryan, Donovan-Banfield I'ah, Hartman Hassan, Løchen Alessandra, Peacock Thomas P, Ruis Christopher

Abstract excerpt

Molnupiravir, an antiviral medication widely used against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), acts by inducing mutations in the virus genome during replication. Most random mutations are likely to be deleterious to the virus and many will be lethal; thus, molnupiravir-induced elevated mutation rates reduce viral load1,2. However, if some patients treated with molnupiravir do not fully...

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Identifiers

PMID: 37748513
DOI: 10.1038/s41586-023-06649-6
PMCID: PMC10651478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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