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Article

TP53: the unluckiest of genes?

Cell death and differentiation - 1 Feb 2025

Joerger Andreas C, Stiewe Thorsten, Soussi Thierry

Abstract excerpt

The transcription factor p53 plays a key role in the cellular defense against cancer development. It is inactivated in virtually every tumor, and in every second tumor this inactivation is due to a mutation in the TP53 gene. In this perspective, we show that this diverse mutational spectrum is unique among all other cancer-associated proteins and discuss what drives the selection of TP53 mutations in cancer. We...

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Identifiers

PMID: 39443700
DOI: 10.1038/s41418-024-01391-6
PMCID: PMC11803090

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TP53

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