Article

MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis

2022-04-15

Abstract excerpt

<h4>Background: </h4> Small cell lung cancer (SCLC) is an aggressive lung cancer subtype that is associated with high recurrence and poor prognosis. Due to a lack of potential drug targets, SCLC patients have few therapeutic options. MicroRNAs (miRNAs) provide an interesting repertoire of therapeutic molecules; however, the identification of miRNAs regulating SCLC growth and metastasis and their precise regulatory...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91f21bd1-8dbe-5fcb-b61d-a2951588f4db
DOI: 10.21203/rs.3.rs-1538869/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axisDOI 10.21203/rs.3.rs-1538869/v1Read

MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axisSemantic proximity Read

FOXM1 targeting alters AURKB activity and reshapes antitumor immunity to curb the progression of small cell lung cancerSemantic proximity Read

Identification of lncRNA, miRNA and mRNA expression profiles and ceRNA Networks in small cell lung cancerSemantic proximity Read

Signal pathways and precision therapy of small-cell lung cancerSemantic proximity Read

Exosome-Derived LncRNA MIR4435-2HG Suppresses Malignant Phenotypes and Brain Metastasis in Small Cell Lung CancerSemantic proximity Read

Lung CSC-derived exosomal miR-210-3p contributes to a pro-metastatic phenotype in lung cancer by targeting FGFRL1.Semantic proximity Read

Advances in Small-Cell Lung Cancer (SCLC) Translational Research.Semantic proximity Read

CXCL-CXCR2 signaling drives cancer-endothelium interactions in SCLC metastatic seedingSemantic proximity Read

MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancerSemantic proximity Read

CircRUNX1 drives the malignant phenotypes of lung adenocarcinoma through mediating the miR-5195-3p/HMGB3 network.Semantic proximity Read

SSRP1 Promotes Lung Cancer Progression by Blocking the WNT Pathway and is Negatively Regulated by miRNA-28-5pSemantic proximity Read

RNA sequencing analysis of small cell lung cancer reveals candidate chemotherapy insensitivity long noncoding RNAs and microRNAsSemantic proximity Read