Article
Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association.
European heart journal - 7 Feb 2024
Ardissino Maddalena, Morley Alec P, Slob Eric A W, Schuermans Art, Rayes Bilal, Raisi-Estabragh Zahra, de Marvao Antonio, Burgess Stephen, Rogne Tormod, Honigberg Michael C, Ng Fu Siong
Abstract excerpt
BACKGROUND AND AIMS: Low birth weight is a common pregnancy complication, which has been associated with higher risk of cardiometabolic disease in later life. Prior Mendelian randomization (MR) studies exploring this question do not distinguish the mechanistic contributions of variants that directly influence birth weight through the foetal genome (direct foetal effects), vs. variants influencing birth weight...
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