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Article

Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study.

Cardiovascular diabetology - 12 Dec 2023

Kong Lijie, Wang Yiying, Ye Chaojie, Dou Chun, Liu Dong, Xu Min, Zheng Jie, Zheng Ruizhi, Xu Yu, Li Mian, Zhao Zhiyun, Lu Jieli, Chen Yuhong, Wang Weiqing, Liu Ruixin, Bi Yufang, Wang Tiange, Ning Guang

Abstract excerpt

BACKGROUND: Previous observational studies have documented an inverse association of birthweight with myocardial infarction (MI) but a positive association with atrial fibrillation (AF). However, the causality of these associations and the underlying mediating pathways remain unclear. We aimed to investigate the causal effects of birthweight, incorporating both fetal and maternal genetic effects, on MI and AF,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38087288
DOI: 10.1186/s12933-023-02062-5
PMCID: PMC10716951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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