Article
Maternal genetic variation accounts in part for the associations of maternal size during pregnancy with offspring cardiometabolic risk in adulthood.
PloS one - 1 Jan 2014
Wander Pandora L, Hochner Hagit, Sitlani Colleen M, Enquobahrie Daniel A, Lumley Thomas, Lawrence Gabriela M, Burger Ayala, Savitsky Bella, Manor Orly, Meiner Vardiella, Hesselson Stephanie, Kwok Pui Y, Siscovick David S, Friedlander Yechiel
Abstract excerpt
BACKGROUND: Maternal pre-pregnancy body-mass index (ppBMI) and gestational weight gain (GWG) are associated with cardiometabolic risk (CMR) traits in the offspring. The extent to which maternal genetic variation accounts for these associations is unknown. METHODS/RESULTS: In 1249 mother-offspring pairs recruited from the Jerusalem Perinatal Study, we used archival data to characterize ppBMI and GWG and follow-up...
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