Article
CHB patients with rtA181T-mutated HBV infection are associated with higher risk hepatocellular carcinoma due to increases in mutation rates of tumour suppressor genes.
Journal of viral hepatitis - 1 Dec 2023
Ning Qiqi, Yang Tongwang, Guo Xianghua, Huang Yanxiang, Gao Yuxue, Liu Mengcheng, Yang Pengxiang, Guan Yuanyue, Liu Ning, Wang Yang, Chen Dexi
Abstract excerpt
The HBV rtA181T mutation is associated with an increased risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). This study aimed to evaluate the mechanism by which rtA181T mutation increases the risk of HCC. We enrolled 470 CHB patients with rtA181T and rtA181V mutation in this study; 68 (22.15%) of the 307 patients with rtA181T mutation and 22 (13.5%) of the 163 patients with rtA181V...
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