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Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.

Antiviral research - 1 Jun 2018

Zhao Li, Li Xiaodong, Cheng Yongqian, Chen Rongjuan, Shao Jinman, Zhou Yi, Li Qi, Liao Hao, Zhao Yangyang, Liu Lujie, Su Heling, Liu Yongming, Liu Yan, Xu Dongping

Abstract excerpt

The study aimed to characterize rtA181T/sW172stop (*) and rtA181T/sW172non-stop mutations of hepatitis B virus (HBV). Total of 22,009 patients who visited Beijing 302 Hospital from 2007 to 2016 were enrolled. These patients all received nucleos(t)ide analogues (NAs) treatment and their serum samples were collected for sequence analysis of HBV reverse-transcriptase (RT) and S regions. The rtA181T mutation was...

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PMID: 29630974
DOI: 10.1016/j.antiviral.2018.04.003

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