Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

PloS one - 1 Jan 2014

Wu Yan, Gan Yu, Gao Fumin, Zhao Zhimei, Jin Yan, Zhu Yu, Sun Zhihan, Wu Hao, Chen Taoyang, Wang Jinbing, Sun Yan, Fan Chunsun, Xiang Yongbing, Qian Gengsun, Groopman John D, Gu Jianren, Tu Hong

Abstract excerpt

BACKGROUND/AIM: Hepatitis B Virus (HBV) mutations play a role in the development of hepatocellular carcinoma (HCC). However, the association between HBV polymerase gene mutations and HCC has not been reported. In this study, we conducted a multi-stage study to identify HCC-related mutations in the reverse transcriptase (RT) domain of the HBV polymerase gene. METHODS: A total of 231 HCCs and 237 non-HCC controls...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Hepatitis B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to Liver Neoplasms

Share to Mutation Rate

Share to Reproducibility of Results

Share to RNA-Directed DNA Polymerase

Share to Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 24788140
DOI: 10.1371/journal.pone.0094864
PMCID: PMC4006920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.PMID 24788140Read ↗

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.Semantic proximity Read ↗

Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.Semantic proximity Read ↗

Accumulation of mutations in reverse transcriptase of hepatitis B virus is associated with liver disease severity in treatment-naïve Chinese patients with chronic hepatitis B.Semantic proximity Read ↗

Analysis of reverse transcriptase gene mutations in the hepatitis B virus at a university hospital in Korea.Semantic proximity Read ↗

A3G-induced mutations show a low prevalence and exhibit plus-strand regional distribution in hepatitis B virus DNA from patients with non-hepatocellular carcinoma (HCC) and HCC.Semantic proximity Read ↗

Association between HLA-DQA1/DRB1 polymorphism and development of hepatocellular carcinoma during entecavir treatment.Semantic proximity Read ↗

CHB patients with rtA181T-mutated HBV infection are associated with higher risk hepatocellular carcinoma due to increases in mutation rates of tumour suppressor genes.Semantic proximity Read ↗

F221Y mutation in hepatitis B virus reverse transcriptase is associated with hepatocellular carcinoma prognosis following liver resection.Semantic proximity Read ↗

Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2.Semantic proximity Read ↗

Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients.Semantic proximity Read ↗

Characterization of mutations in the reverse transcriptase region of hepatitis B virus in treated and untreated chronic hepatitis B patients.Semantic proximity Read ↗

Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.