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Article

HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.

Virologica Sinica - 1 Oct 2023

Zhao Baoxin, Qiao Hongxiu, Zhao Yan, Gao Zhiyun, Wang Weijie, Cui Yan, Li Jian, Guo Zhanjun, Chuai Xia, Chiu Sandra

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is one of the leading causes of hepatocellular carcinoma (HCC). The HBV genome is prone to mutate and several variants are closely related to the malignant transformation of liver disease. G1896A mutation (G to A mutation at nucleotide 1896) is one of the most frequently observed mutations in the precore region of HBV, which prevents HBeAg expression and is strongly...

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Identifiers

PMID: 37331658
DOI: 10.1016/j.virs.2023.06.004
PMCID: PMC10590694

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