Article
Genetic Evidence Supporting Causal Roles of mTOR-Dependent Proteins in Rheumatic Fever: A Two-Sample Randomized Mendelian Study.
Advances in therapy - 1 Apr 2023
Mu Yan-Fei, Wang Qian, Hu Jing-Xi, Wang Qi, Zhang Yao-Chen, Fan Ke-Yi, Han Zi-Yi, Zhang He-Yi, Cheng Ting, Zhao Rong, Song Shan, Qiao Jun, Zhang Sheng-Xiao, Wang Cai-Hong
Abstract excerpt
BACKGROUND: The expression of signaling molecules downstream of the mammalian target of rapamycin (mTOR) is dysregulated in patients with rheumatic fever (RF), but the causality of mTOR on RF remains unknown. This study aimed to investigate the causal effects of the mTOR-dependent proteins in RF. METHODS: The summary data for targets of the mTOR signaling were acquired from the publicly available INTERVAL study...
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