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Article

The correlation between clinical outcomes and genomic analysis with high risk factors for the progression of osteosarcoma.

Molecular oncology - 1 Apr 2024

Liu Weifeng, Cheng Huanqing, Huang Zhen, Li Yaping, Zhang Yanrui, Yang Yongkun, Jin Tao, Sun Yang, Deng Zhiping, Zhang Qing, Lou Feng, Cao Shanbo, Wang Huina, Niu Xiaohui

Abstract excerpt

Osteosarcoma (OS) is a rare but aggressive malignancy. Despite previous reports, molecular characterization of this disease is not well understood, and little is known regarding OS in Chinese patients. Herein, we analyzed the genomic signatures of 73 Chinese OS cases. TP53, NCOR1, LRP1B, ATRX, RB1, and TFE3 were the most frequently mutated gene in our OS cohort. In addition, the genomic analysis of Western OS...

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Source

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Identifiers

PMID: 37727135
DOI: 10.1002/1878-0261.13526
PMCID: PMC10994228

Genes

ATRX
LRP1B
NCOR1
RB1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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