Article
Pan-cancer analysis reveals molecular patterns associated with age.
Cell reports - 7 Dec 2021
Shah Yajas, Verma Akanksha, Marderstein Andrew R, White Jessica, Bhinder Bhavneet, Garcia Medina J Sebastian, Elemento Olivier
Abstract excerpt
Older age is a strong risk factor for several diseases, including cancer. The etiology and biology of age-associated differences among cancers are poorly understood. To address this knowledge gap, we aim to delineate differences in tumor molecular characteristics between younger and older patients across a variety of tumor types from The Cancer Genome Atlas. We show that these groups exhibit widespread molecular...
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