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Article

The pattern of rpoB gene mutation of Mycobacterium tuberculosis and predictors of rifampicin resistance detected by GeneXpert MTB/RIF assay in Tanzania.

PloS one - 1 Jan 2024

Torokaa Peter Richard, Majigo Mtebe V, Kileo Heledy, Urio Loveness, Mbwana Mariam R, Monah Mariam C, Ntibabara Sephord Saul, Kimambo Jasper, Seleman Paschal, Franklin Collins, Balama Robert, Kisonga Riziki M, Joachim Agricola

Abstract excerpt

INTRODUCTION: Antimicrobial resistance in Mycobacterium tuberculosis (MTB) poses a significant challenge to tuberculosis (TB) management worldwide. Rifampicin resistance (RR) has been associated with the rpoB gene mutation. No study was conducted in Tanzania to determine the commonest mutation. The inconsistent findings from various studies support the need to determine whether reported mutation patterns are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39186753
DOI: 10.1371/journal.pone.0296563
PMCID: PMC11346956

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