Article

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples

2021-12-07

Abstract excerpt

Participant overlap has been thought to induce overfitting bias into Mendelian randomization (MR) and polygenic risk score (PRS) studies. This hinders the potential research into many unique traits and disease outcomes from large-scale biobanks. Here, we evaluated a block jackknife resampling framework for genome-wide association studies (GWAS) and PRS construction to mitigate the influence of overfitting bias on...

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Literature Corpus work: 7657b9dc-1272-54b9-a498-2dc46219cd18
DOI: 10.1101/2021.12.03.21267246

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