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Discovery and Validation of Methylation Signatures in Circulating Cell-Free DNA for the Detection of Colorectal Cancer

13 Aug 2024

Abstract excerpt

This study was conducted with the primary objective of assessing the performance of cfDNA methylation in the detection of colorectal cancer (CRC). Five tumor tissue, 20 peripheral blood leucocyte, and 169 cfDNA samples were collected for whole-genome bisulfite sequencing (WGBS) analysis. Bioinformatic analysis was conducted to identify differentially methylated regions (DMRs) and their functional characteristics....

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Cancer Genomics and Diagnostics
Epigenetics and DNA Methylation
Pancreatic and Hepatic Oncology Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39199384
DOI: 10.3390/biom14080996

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