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Hypothesis: amyotrophic lateral sclerosis and environmental pollutants.

Muscle & nerve - 1 Aug 2020

Swash Michael, Eisen Andrew

Abstract excerpt

Genetic, epigenetic, and environmental factors are relevant in the causation of amyotrophic lateral sclerosis (ALS) in a multistep cascade. We suggest that exposure to environmental pollutants in early life is one such factor. ALS was first described in the 19th century in the context of the Industrial Revolution that began more than 50 years earlier. The rising incidence of ALS thereafter correlates with...

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PMID: 32134532
DOI: 10.1002/mus.26855

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