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Article

Polymorphisms in the aldehyde dehydrogenase 2 and dopamine β hydroxylase genes are not associated with Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Apr 2014

Komatsu Miwa, Shibata Nobuto, Ohnuma Tohru, Kuerban Bolati, Tomson Katrin, Toda Aiko, Tagata Yuko, Nakada Tomoko, Shimazaki Hiromi, Arai Heii

Abstract excerpt

Since ethanol and its metabolite, acetaldehyde, are directly neurotoxic, alcohol intake could affect the development of Alzheimer's disease (AD). Mitochondrial aldehyde dehydrogenase 2 (ALDH2) metabolizes acetaldehyde into acetate and also protects against oxidative stress, playing an important role in the development of AD. The activity of dopamine β hydroxylase (DBH) is reduced in the hippocampus and neocortex...

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Source

Identifiers

PMID: 24201835
DOI: 10.1007/s00702-013-1112-z

Genes

DBH
ALDH2
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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