Article
Evaluating the usefulness of C5 and C5AR1 as genetic biomarkers of IgA-mediated vasculitis.
Molecular medicine (Cambridge, Mass.) - 27 Jul 2025
Batista-Liz Joao Carlos, Calvo-Río Vanesa, Mora-Gil María Sebastián, Leonardo María Teresa, Peñalba Ana Cristina, Martín-Penagos Luis, Narváez Javier, Sevilla-Pérez Belén, Callejas-Rubio José Luis, Gabrie Ligia, Sánchez Rafael Gálvez, Caminal-Montero Luis, Collado Paz, Valls María José Rodríguez, de Argila Diego, Quiroga-Colina Patricia, Vicente-Rabaneda Esther Francisca, Rubio Esteban, Luque Manuel León, Blanco-Madrigal Juan María, Galíndez-Agirregoikoa Eva, Blanco Ricardo, Pulito-Cueto Verónica, López-Mejías Raquel
Abstract excerpt
BACKGROUND: IgA-mediated vasculitis (IgAV) is a complex inflammatory disease. Unravelling its genetic background would allow us to identify genetic biomarkers that may be used as additional tools in its daily management, helping to solve the clinical challenge that this vasculitis entails. C5 is a potent immune mediator that is proteolytically processed to generate C5a, a potent anaphylatoxin that exerts its...
Read the complete abstract on PubMedTopics
- Humans
- Receptor, Anaphylatoxin C5a
- Male